[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid

Name	fosfomycin
Synonyms	mk-955 fosfocina FOSFOMYCIN fosfomycin fosfonomycin PHOSPHOMYCIN (3-Methyloxiran-2-yl)phosphonic acid [(3S)-3-methyloxiran-2-yl]phosphonic acid Phosphonic acid, (2R,3S)-3-methyloxiranyl- [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
CAS	23155-02-4
EINECS	245-463-1
InChI	InChI=1/C3H7O4P/c1-2-3(7-2)8(4,5)6/h2-3H,1H3,(H2,4,5,6)/t2-,3+/m0/s1

Molecular Formula	C3H7O4P
Molar Mass	138.06
Density	1.56±0.1 g/cm3(Predicted)
Melting Point	94°C
Boling Point	342.7±52.0 °C(Predicted)
Flash Point	161.03°C
Vapor Presure	0mmHg at 25°C
Appearance	solid
pKa	3.20±0.40(Predicted)
Refractive Index	1.486
Physical and Chemical Properties	Crystals with a melting point of about 94 °c. Clinical general use of its sodium or calcium salt, sodium salt for injection, calcium salt for oral use. Its sodium salt is white crystalline powder, with strong hygroscopicity, easily soluble in water, slightly soluble in ethanol, ether and other organic solvents. Its calcium salt is white powder, slightly soluble in water, insoluble in acetone, benzene, chloroform and ether.
Use	Has a good effect on Pseudomonas aeruginosa, Proteus, Escherichia coli, Serratia and Staphylococcus

Raw Materials

use effect	for us, this is an alternative treatment." Dr Ilias Karaiskos, a Greek research leader, said, "We think if we have quinolones available, then we should use quinolones, because many studies have shown that quinolones are fully effective in the prostate and have the strongest ability to enter prostate tissue. But if the pathogenic microorganism in the patient's body is resistant to quinolones, then I will use fosfomycin.
use	this product is a broad-spectrum antibiotic, which plays a bactericidal role by preventing the synthesis of bacterial cell walls, and is effective for both gram-half positive and negative bacteria. Mainly used for Staphylococcus aureus, Dandobacterium, Proteus mirabilis, Shigella and other infections. It has a good effect on Pseudomonas aeruginosa, Proteus, Escherichia coli, Serratia and Staphylococcus.
production method	using propargyl alcohol as raw material, through esterification, rearrangement, hydrolysis, isomerization, disodium propynyl phosphate. Then it is hydrolyzed, isomerized, and hydrogenated to obtain cis-propylene phosphoric acid. Pisacryl phosphoric acid is salted with (±)-a-phenethylamine, epoxidation, and resolution to obtain fosfomycin.

Last Update：2024-04-09 15:16:44

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CAS: 23155-02-4
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Raw Materials for [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid

Acetophenone
Phosphorus trichloride

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